In the ear duct: insert the content of the syringe in the duct and subsequently massage the ear’s base.
On the skin: wet the chosen zone until the entire surface is covered.
Repeat the application is necessary or follow your veterinarian’s advice.
Tris-NAC ® is an innovative combination based on the synergies between N-Acetyl Cysteine and Tris-EDTA that is applied as an efficient support to prevent the formation of the bacterial biofilm. When the biofilm already exists, Tris-NAC ® helps its disaggregation.
WHAT IS BIOFILM?
Biofilm: a bacterial resistance mechanism that needs to be accounted for.
It is a heterogeneous structure constituted by a matrix of extracellular polymers englobing bacterial populations thus protected from antibiotics, cleansing agents and disinfectants, as well as from the immune system. Biofilm can form on medical material as well as on animal tissues.
This makes bacteria protected in that way 100 to 1000 times more resistant than in their free form.
Some bacterial species, incuding Staphylococcus pseudintermedius, Pseudomonas aeruginosa (mainly in ear infections in dogs (figs. 1 and 2)), Proteus mirabilis, et Escherichia coli. possess the capacity to form a biofilm, particularly during skin seborrhoea in dogs.
Figure 1 : Purulent substance with a biofilm during a canine ear infection due to Pseudomonas.
Figure 2 : Auricular cytology with low magnification of the sample seen in figure 1. The biofilm’s amorphous protein matrix that traps bacteria and neutrophils is visible.